Amyloid � peptide 1?42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology
نویسندگان
چکیده
منابع مشابه
Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline.
Sporadic, late-onset Alzheimer disease (AD) constitutes the most frequent cause of dementia in the elderly population. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis/lipohyalinosis (AS/LH). The present study was carried out to examine the coincidence of these small vessel pathologie...
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Cerebral amyloid angiopathy (CAA) affects brain parenchymal and leptomeningeal arteries and arterioles but sometimes involves capillaries (capCAA) with spread of the amyloid into the surrounding neuropil, that is, dyshoric changes. We determined the relationship between capCAA and larger vessel CAA, β amyloid (Aβ) plaques, neurofibrillary changes, inflammation, and apolipoprotein E (APOE) in 22...
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We reviewed the recent progress in cerebral amyloid research, especially on the amyloid ß/Α4 (Αß) peptide from results in our laboratory and those reported in the literature. Cerebral amyloid deposition is an extracellular deposition in the brain and brain blood vessels of insoluble aggregates of the Αß peptide. Isolation and sequencing of the peptide from senile plaques and cerebrovascular amy...
متن کاملCerebral Amyloid Angiopathy and Alzheimer's Disease.
Cerebral amyloid angiopathy (CAA) is increasingly recognized as a major contributor of Alzheimer's disease (AD) pathogenesis. To date, vascular deposits and not parenchymal plaques appear more sensitive predictors of dementia. Amyloid deposition in and around cerebral blood vessels plays a central role in a series of response mechanisms that lead to changes in the integrity of the blood-brain b...
متن کاملCerebral amyloid angiopathy.
Brain of a 66 year old woman with a four year history of progressive dementia with episodes of encephalopathy. Opposite: Multiple small, cystic, and occasionally confluent cortical scars (arrows) were restricted to the cerebrum and were due to cerebral amyloid angiopathy. Histological examination of the cortex in the postmortem brain showed numerous neuritic plaques and neurofibrillary tangles ...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2004
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-004-0866-7